P4668
吡喹酮
anthelminic, neurogenic
别名:
2-(环己基羰基)-1,2,3,6,7-11b-六氢-4H-吡嗪并-[2,1-a]-异喹啉-4-酮
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关于此项目
经验公式（希尔记法）:
C19H24N2O2
化学文摘社编号:
分子量:
312.41
UNSPSC Code:
51452701
NACRES:
NA.85
PubChem Substance ID:
EC Number:
259-559-6
Beilstein/REAXYS Number:
761557
MDL number:
InChI key
FSVJFNAIGNNGKK-UHFFFAOYSA-N
InChI
1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
SMILES string
O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
form
powder or crystals
antibiotic activity spectrum
parasites
mode of action
cell membrane | interferes
storage temp.
−20°C
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Application
吡喹酮是一种强效驱虫剂，可用于对抗血吸虫和多种绦虫的侵扰。它用于研究电压门控Ca2+ 通道，是一种潜在的小分子神经源性药物.
Biochem/physiol Actions
吡喹酮会增加被盖层对 Ca2+的渗透性，从而诱发的肌肉收缩和死亡。吡喹酮会导致血吸虫被盖层空泡的形成和分解。它对成年蠕虫比对幼年成年更有效。它会抑制葡萄糖吸收，从而降低糖水平，刺激乳酸释放。吡喹酮是一种强效驱虫剂，可用于对抗寄生扁虫（吸虫和绦虫）。最近的研究表明，吡喹酮能够与电压门控Ca2+ 通道亚基的变体以及肌动蛋白（某些 Ca2+通道的组分）结合。
Other Notes
1g,5g,25g
保存于密闭容器内，置于干燥通风处。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
Dan Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(44), 15983-15995 (2011-11-04)
There is intense interest in developing methods to regulate proliferation and differentiation of stem cells into neuronal fates for the purposes of regenerative medicine. One way to do this is through in vivo pharmacological engineering using small molecules. However, a
R J Martin et al.
Parasitology, 114 Suppl, S111-S124 (1997-01-01)
This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamategated chloride channels found only in
Fiona Ronketti et al.
Bioorganic & medicinal chemistry letters, 17(15), 4154-4157 (2007-06-09)
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These
Yuxiang Dong et al.
Bioorganic & medicinal chemistry letters, 20(8), 2481-2484 (2010-03-23)
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of these had significant activity against adult worms, but, unlike praziquantel, six
Jean T Coulibaly et al.
PLoS neglected tropical diseases, 7(3), e2109-e2109 (2013-04-05)
The Kato-Katz technique is widely used for the diagnosis of Schistosoma mansoni, but shows low sensitivity in light-intensity infections. We assessed the accuracy of a commercially available point-of-care circulating cathodic antigen (POC-CCA) cassette test for the diagnosis of S. mansoni
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