P4687
青霉素G 钾盐
powder, suitable for mouse embryo cell culture
别名:
苄青霉素 钾盐
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关于此项目
经验公式（希尔记法）:
C16H17KN2O4S
化学文摘社编号:
分子量:
372.48
EC Number:
204-038-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3832841
MDL number:
InChI key
IYNDLOXRXUOGIU-LQDWTQKMSA-M
InChI
1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
SMILES string
[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
form
powder
potency
1440-1680 units per mg
technique(s)
cell culture | embryo: suitable
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
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General description
Chemical structure: β-lactam
Application
Recommended for use in embryo culture at approximaterly 100,000 units/L (60 mg/L). Solutions should be filter sterilized and stored at 2-8 °C for up to 1 week, −20 °C for extended periods. Solutions are stable at 37 °C for 3 days.
Used in cell culture in combination with streptomcyin and other antibiotics.
Biochem/physiol Actions
作用机制：青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联，从而抑制细胞壁合成。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining.
Eleonor G Lago et al.
Sexually transmitted diseases, 40(2), 85-94 (2013-01-18)
The aim of this study was to investigate clinical features and outcomes of children treated for congenital syphilis (CS). Infants born alive in the public sector of São Lucas Hospital, Porto Alegre, Brazil, 1997 to 2004, whose mothers had syphilis
Lemierre's syndrome in systemic lupus erythematosus: a report of two cases.
J C Rødgaard et al.
Scandinavian journal of rheumatology, 42(2), 167-168 (2013-01-15)
Congenital syphilis: the story of a greek tragedy.
Sarah Hawkes
Sexually transmitted diseases, 40(2), 95-96 (2013-01-17)
Tina Lund Leunbach et al.
Ugeskrift for laeger, 175(11), 742-743 (2013-03-14)
A pregnant Caucasian woman with newly diagnosed syphilis in the secondary stage was hospitalized for observation while being treated with penicillin. After one dose of penicillin the foetus was delivered by a caesarean section at gestational age 28 weeks +
Muneki Hotomi et al.
PloS one, 8(3), e58124-e58124 (2013-03-14)
The protection against pneumococcal infections provided by currently available pneumococcal polysaccharide conjugate vaccines are restricted to the limited number of the serotypes included in the vaccine. In the present study, we evaluated the distribution of the pneumococcal capsular type and
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