产品名称
Anti-Peripherin antibody, Mouse monoclonal, clone 8G2, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
8G2, monoclonal
form
buffered aqueous solution
species reactivity
rat, bovine, pig, mouse, rabbit, feline, human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract from rat PC12 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PRPH(5630)
mouse ... Prph(19132)
rat ... Prph(24688)
Biochem/physiol Actions
Peripherin is upregulated during pheochromocytoma PC12 cell differentiation. Later studies have detected peripherin also in certain central nervous system (CNS) neurons.
eripherin has been linked with axonal extension and regeneration of nerve fibers. It also has a role in neurite outgrowth propagation. Peripherin is a substrate of protein kinase B/Akt. Phosphorylation of this protein is induced after nerve injury.
Application
Anti-Peripherin antibody, Mouse monoclonal has been used in:
- immunohistochemistry
- western blotting
- enzyme linked immunosorbent assay (ELISA)
- immunofluorescence staining
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Peripherin (mouse IgG1 isotype) is derived from the 8G2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the full-length recombinant rat peripherin. Peripherin was originally identified as a neuronal intermediate filament protein-(IF) is thought to be expressed only in the peripheral nervous system (PNS).
Peripherin is an intermediate filament protein. It is expressed in peripheral and enteric neurons. The gene encoding this protein is localized on rat chromosome 7.
Immunogen
full-length recombinant rat peripherin.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Rania Magadmi et al.
Frontiers in cellular neuroscience, 13, 262-262 (2019-07-06)
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external
Suppression of Extensive Neurofilament Phosphorylation Rescues alpha-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death
Lee WC, et al.
PLoS ONE, 7(8), e43883-e43883 (2012)
Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.
Shen, et al.
Scientific Reports, 13, 4670-4670 (2023)
Identification of peripherin as a Akt substrate in neurons.
Konishi H
The Journal of Biological Chemistry (2007)
New insights into peripherin expression in cochlear neurons.
Lallemend F
Neuroscience (2007)
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