P5679
3-Propylxanthine
≥99%, solid
别名:
Enprofylline
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关于此项目
经验公式（希尔记法）:
C8H10N4O2
化学文摘社编号:
分子量:
194.19
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
255-201-8
MDL number:
Beilstein/REAXYS Number:
1116213
assay
≥99%
form
solid
color
white
solubility
DMSO: soluble, H2O: slightly soluble (Solutions should be stored at 4°C.), alcohol: soluble (Solutions should be stored at 4°C.)
SMILES string
CCCN1C(=O)NC(=O)c2[nH]cnc12
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)
Biochem/physiol Actions
Weak competitive antagonist at both A1 and A2 adenosine receptors.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
T Kuzuya et al.
Biological & pharmaceutical bulletin, 20(10), 1051-1055 (1997-11-14)
The pharmacokinetic characteristics, peritoneal permeability and hydrophobicity of three xanthine derivatives, theophylline, enprofylline and 1-methyl-3-propylxanthine (MPX), were investigated in rats. Isotonic saline (30 ml) containing xanthine (2.5, 5 and 10 mg/kg) and blue dextran (0.2%) was administered intraperitoneally. The pharmacokinetic
Carmen Diniz et al.
European journal of pharmacology, 460(2-3), 191-199 (2003-02-01)
Adenosine receptors involved in modulation of contractions were characterized in the bisected rat vas deferens by combining pharmacological and immunohistochemical approaches. In both portions, noradrenaline-elicited contractions were enhanced by the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA), and inhibited by the
D Ukena et al.
European journal of pharmacology, 117(1), 25-33 (1985-10-29)
The effects of enprofylline were studied on A1 adenosine receptors of rat fat cells and on A2 adenosine receptors of human platelets and of guinea-pig lung. Enprofylline antagonized the 5'-N-ethylcarboxamidoadenosine (NECA)-induced stimulation of platelet adenylate cyclase activity with a KB
P Nieri et al.
British journal of pharmacology, 134(4), 745-752 (2001-10-19)
1. Adenosine produced a biphasic lowering of the mean BP with a drastic bradycardic effect at the highest doses. The first phase hypotensive response was significantly reduced by the nitric oxide (NO) synthase inhibitor L-NAME. 2. The A(2a)/A(2b) agonist NECA
I Feoktistov et al.
Biochemical pharmacology, 62(9), 1163-1173 (2001-11-14)
The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure-activity relationships (SARs) of xanthine derivatives, we designed a novel selective adenosine A(2B) receptor antagonist, 3-isobutyl-8-pyrrolidinoxanthine (IPDX), with potency greater than that
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