P5748
Anti-Parkin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-PARK2, Anti-PRKN, Anti-PRKN2, Anti-Parkinson disease protein 2, Anti-Parkinson juvenile disease protein 2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
immunohistochemistry: 1 μg/mL using pedunculopontine tegmental nucleus in rat brain, western blot: 0.5 μg/mL using recombinant human parkin
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PARK2(5071)
mouse ... Park2(50873)
rat ... Park2(56816)
General description
Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains, that is, RING0, RING1, in between ring (IBR) and RING2. Parkin is a 465 amino acid protein which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.
Immunogen
synthetic peptide CI(298)KELHHFRILGEEQYN(313), corresponding to amino acid residues 298-313 from human parkin. The sequence is completely conserved between human, mouse, and rat.
Application
Anti-Parkin antibody produced in rabbit has been used in Western blotting and immunohistochemistry.
Biochem/physiol Actions
The expression of parkin RBR E3 ubiquitin protein ligase has been found to be altered in various malignancies. Mutations in the gene encoding it have been linked to autosomal recessive juvenile Parkinson (ARJP) disease. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation.
Physical form
Solution of 100 μg (1 mg/mL) in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
含少量动物源组分生物产品
此项目有
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance
Xiangnan Zhang
Autophagy (2013)
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury
Xiangnan Z
Autophagy (2014)
Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients.
Naseem A
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2017)
Xiangnan Zhang et al.
Autophagy, 9(9), 1321-1333 (2013-06-27)
Cerebral ischemia-reperfusion (I-R) is a complex pathological process. Although autophagy can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its contribution to the fate of neurons remains largely unknown. In the present investigation, we found
PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus.
Al-Qahtani AA
Annals of Hepatology (2016)
相关内容
Datasheet
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