P5865
Rp-8-PIP-cAMPS
≥98% (HPLC), solid
别名:
8-Piperidinoadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer sodium salt
方案
≥98% (HPLC)
表单
solid
分子量
apparent mol wt 457.40
储存温度
−20°C
SMILES字符串
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@@]([O-])(=S)O[C@H]4[C@H]3O)c(nc12)N5CCCCC5
InChI
1S/C15H21N6O5PS.Na/c16-12-9-13(18-7-17-12)21(15(19-9)20-4-2-1-3-5-20)14-10(22)11-8(25-14)6-24-27(23,28)26-11;/h7-8,10-11,14,22H,1-6H2,(H,23,28)(H2,16,17,18);/q;+1/p-1/t8-,10-,11-,14-,27-;/m1./s1
InChI key
ILHHHOJPVCBSBI-RYTXRTGRSA-M
生化/生理作用
Site-selective, lipophilic analogue of the phosphodiesterase-stable protein kinase A inhibitor Rp-cAMPS (Prod. No. A-165).
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
D Ogreid et al.
European journal of biochemistry, 221(3), 1089-1094 (1994-05-01)
8-Piperidino-cAMP has been shown to bind with high affinity to site A of the regulatory subunit of cAMP-dependent protein kinase type I (AI) whereas it is partially excluded from the homologous site (AII) of isozyme II [Ogreid, D., Ekanger, R.
Haiyan Liu et al.
Molecular pharmacology, 76(6), 1290-1301 (2009-09-08)
Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K+ channels whose inhibition by cAMP is coupled to membrane depolarization and cortisol secretion through complex signaling mechanisms. cAMP analogs with substitutions in the 6 position of the adenine ring selectively activate
Amod Godbole et al.
Nature communications, 8(1), 443-443 (2017-09-07)
A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the
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