Merck
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文件

安全信息

P6628

Sigma-Aldrich

毛果芸香碱 硝酸盐

≥98% (HPLC)

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经验公式（希尔记法）:
C11H16N2O2 · HNO3
CAS号:
148-72-1
分子量:
271.27
Beilstein:
4171406
EC 号:
205-723-7
MDL编号:
MFCD00078497
PubChem化学物质编号:
57654548
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]25/D +83°, c = 10 in H2O(lit.)

颜色

white

溶解性

H2O: 100 mg/mL

SMILES string

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChI key

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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应用

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

生化/生理作用

非选择性毒蕈碱型乙酰胆碱受体激动剂；用于建立癫痫的实验模型。
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

象形图

Flame over circleSkull and crossbones
GHS03,GHS06

警示用语：

Danger

危险声明

H272 - H302 - H330

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

储存分类代码

5.1B - Oxidizing hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats
Nie Z, et al.
American Journal of Respiratory Cell and Molecular Biology, 51(2), 251-261 (2014)
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures
Andrioli A, et al.
Epilepsia, 50(4), 832-848 (2009)
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Kevin D Phelan et al.
Molecular pharmacology, 83(2), 429-438 (2012-11-29)
Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated
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