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Merck
CN

P7383

Pyrophosphatase, Nucleotide from Crotalus adamanteus venom

Type II, lyophilized powder, 4-8 units/mg protein, vial of ~25 units

别名:

Dinucleotide nucleotidohydrolase

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化学文摘社编号:
UNSPSC Code:
12352204
MDL number:
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type

Type II

form

lyophilized powder

specific activity

4-8 units/mg protein

packaging

vial of ~25 units

foreign activity

5′-nucleotidase <0.003 units/mg protein, alkaline phosphatase <0.002 units/mg protein, phosphodiesterase 0.2 - 0.4 units/mg protein

storage temp.

−20°C

Physical form

Lyophilized powder containing approx. 35% Tris buffer salts.

Other Notes

One unit will hydrolyze 1.0 μmole of β-NAD to NMN and AMP per min at pH 7.4 at 37 °C in the presence of Mg ions.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Soheil Naderi et al.
Human immunology, 69(12), 833-836 (2008-10-07)
Defects in Fas receptor signaling lead to compromised maintenance of lymphocyte homeostasis and peripheral immune tolerance, leading in turn to autoimmune disorders. Therefore, agents that can enhance Fas-mediated apoptosis may be therapeutically useful in management of such disorders. In this
Violeta López-Canut et al.
Journal of the American Chemical Society, 132(20), 6955-6963 (2010-05-01)
We here present a theoretical study of the alkaline hydrolysis of methyl p-nitrophenyl phosphate (MpNPP(-)) in aqueous solution and in the active site of nucleotide pyrophosphatase/phosphodiesterase (NPP). The analysis of our simulations, carried out by means of hybrid quantum mechanics/molecular
Khalid M Khan et al.
Bioorganic & medicinal chemistry, 17(22), 7816-7822 (2009-10-14)
A series of 1,3,4-oxadiazole-2 (3H)-thiones and 1,3,4-thiadiazole-2 (3H)-thiones were synthesized and evaluated for their inhibitory activities against the two nucleotide pyrophosphatase phosphodiesterase 1 enzymes. Dixon, as well as Lineweaver-Burk plots, and their secondary replots have indicated that the inhibition was
Shiro Ikegawa
Clinical calcium, 21(2), 294-300 (2011-02-04)
ttw (tiptoe walking), a known model mouse of OPLL (ossification of the posterior longitudinal ligament of the spine) is reviewed. ttw is a natural mutant which shows generalized ectopic calcification followed by ossification in the Achiles tendon, ear and spinal
Jamshed Iqbal et al.
Electrophoresis, 29(17), 3685-3693 (2008-09-23)
A new highly sensitive capillary electrophoresis (CE) method applying dynamic coating and on-line stacking for the monitoring of nucleotide pyrophosphatases/phosphodiesterases (NPPs) and the screening of inhibitors was developed. NPP1 and NPP3 are membrane glycoproteins that catalyze the hydrolysis nucleotides, e.g.

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