P7771
乙胺嘧啶
别名:
6-乙基-5-(4-氯苯基)-2,4-嘧啶二胺
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关于此项目
经验公式（希尔记法）:
C12H13ClN4
化学文摘社编号:
分子量:
248.71
EC Number:
200-364-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
219864
MDL number:
InChI key
WKSAUQYGYAYLPV-UHFFFAOYSA-N
InChI
1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
SMILES string
CCC1=NC(N)=NC(N)=C1C2=CC=C(Cl)C=C2
Gene Information
human ... CYP2C9(1559), DHFRP1(573971)
rat ... Dhfr(24312)
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Ramesh Gujjar et al.
Journal of medicinal chemistry, 54(11), 3935-3949 (2011-04-27)
Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance. We previously reported identification of a new class
Alyson M Auliff et al.
Antimicrobial agents and chemotherapy, 54(9), 3927-3932 (2010-06-23)
Plasmodium vivax resistance to antifolates is prevalent throughout Australasia and is caused by point mutations within the parasite dihydrofolate reductase (DHFR)-thymidylate synthase. Several unique mutations have been reported in P. vivax DHFR, and their roles in resistance to classic and
Alexis Nzila et al.
Antimicrobial agents and chemotherapy, 54(6), 2603-2610 (2010-03-31)
Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective. We have previously shown that the di-amino quinazoline QN254 [5-chloro-N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine] is active against the
Tao Wu et al.
Journal of medicinal chemistry, 54(14), 5116-5130 (2011-06-08)
Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimization of cellular
Albert J Ndakala et al.
Journal of medicinal chemistry, 54(13), 4581-4589 (2011-06-08)
A novel class of antimalarial pyrido[1,2-a]benzimidazoles were synthesized and evaluated for antiplasmodial activity and cytotoxicity following hits identified from screening commercially available compound collections. The most active of these, TDR86919 (4c), showed improved in vitro activity vs the drug-resistant K1
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