P8419
5-n-Propyluracil
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关于此项目
经验公式（希尔记法）:
C7H10N2O2
化学文摘社编号:
分子量:
154.17
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
InChI
1S/C7H10N2O2/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)
SMILES string
CCCC1=CNC(=O)NC1=O
InChI key
JHEKLAXXCHLMNM-UHFFFAOYSA-N
form
solid
Application
5-n-Propyluracil is used as a reagent for the synthesis of anti-HIV drugs of the 5-propyluracil class.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A Miazga et al.
Nucleosides, nucleotides & nucleic acids, 29(4-6), 438-444 (2010-06-15)
New homo- and hetero-P(1),P(2)-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, AZT and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]uracil. Anti-HIV properties of the synthesized P(1),P(2)-dinucleotides were evaluated against laboratory syncytia inducing strain HIV-1 in CEM-T4 cells. Anti-HIV
Agnieszka Miazga et al.
Acta biochimica Polonica, 54(4), 863-868 (2007-12-11)
Novel 6-phenylselenenyl-5-propyluracils were synthesized from 5-propyluracil with the use of regioselective synthesis to give 1-[(2-hydroxyethoxy)-methyl]-6-phenylselenenyl-5-propyluracil (6), 1-ethoxymethyl-6-phenylselenenyl-5-propyluracil (9) and 1-benzyloxymethyl-6-phenylselenenyl-5-propyluracil (10). Interaction of these compounds with recombinant HIV-1 reverse transcriptase (RT) was evaluated using a non-isotopic colorimetric method. Compounds 9
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