P8813
普罗替林 盐酸盐
≥99% (TLC), powder
别名:
N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H21N · HCl
化学文摘社编号:
分子量:
299.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
214-956-3
MDL number:
InChI key
OGQDIIKRQRZXJH-UHFFFAOYSA-N
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
SMILES string
Cl[H].CNCCCC1c2ccccc2C=Cc3ccccc13
assay
≥99% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
Gene Information
human ... SLC6A2(6530), SLC6A4(6532)
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Biochem/physiol Actions
Norepinephrine uptake blocker.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Shelf-life of the powder is at least three years at room temperature.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M M Makhay et al.
Pharmacology, biochemistry, and behavior, 63(2), 319-324 (1999-06-17)
The ability of indirectly acting agonists such as norepinephrine uptake inhibitors, serotonin reuptake inhibitors, and atypical antidepressants to substitute for clenbuterol, a beta-2 adrenergic agonist, was examined in rats trained to discriminate 0.03 mg/kg clenbuterol and saline using a fixed-ratio
G L Cohen
Headache, 37(7), 433-436 (1997-07-01)
Twenty-five women with chronic tension-type headaches were treated with protriptyline for 3 months, with attention paid to days of monthly headaches before and while taking the medication, as well as change in weight and side effects. One patient stopped the
G M Barthlen
Respiration; international review of thoracic diseases, 64 Suppl 1, 35-38 (1997-01-01)
Patients with neuromuscular disease may suffer from nocturnal respiratory failure despite normal daytime respiratory function. The physiological reduction in muscle tone during sleep may be life-threatening in a patient with impaired muscle strength. Nocturnal respiratory failure may occur in patients
P Lévy et al.
Sleep, 19(9 Suppl), S101-S110 (1996-11-01)
The spectrum of respiratory sleep disorders has been extended in the last years to include conditions that are less well defined than severe obstructive sleep apnea (OSA). Moderate OSA, snoring, and upper airway resistance syndrome (UARS) represent three conditions in
K Ström et al.
The European respiratory journal, 8(3), 425-429 (1995-03-01)
A daily dose of 20 mg of protriptyline can improve daytime arterial blood gas tensions in chronic obstructive pulmonary disease (COPD). Its usefulness is limited by anticholinergic side-effects. This study examined whether a daily dose of 10 mg of protriptyline
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