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Merck
CN

P8950

Sigma-Aldrich

Monoclonal Anti-HLA-DR−PE antibody produced in mouse

clone HK14, purified immunoglobulin, buffered aqueous solution

别名:

Monoclonal Anti-HLA-DR

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UNSPSC代码:
12352203
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生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

HK14, monoclonal

表单

buffered aqueous solution

种属反应性

human

技术

flow cytometry: 10 μL using 1 × 106 cells

同位素/亚型

IgG2a

UniProt登记号

运输

wet ice

储存温度

2-8°C

基因信息

一般描述

HLA-DR is located on chromosome 6. It is composed of a heavy and light chain, which are two non-covalently associated subunits of molecular weight 33-36 kDa and 24-30 kDa, respectively. These class II antigens are expressed primarily on B cells, and on monocytes and activated T cells, and function in cell-cell recognition in regulation of the immune response.
The previously assigned protein identifier P13761 has been merged into P01911. Full details can be found on the UniProt database.

免疫原

GM-1500 human tumor cell line

生化/生理作用

Recognizes HLA-DR, a product of the human major histocompatibility complex. The antibody is specific for a non-polymorphic HLA-DR determinant.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

制备说明

Prepared by conjugation to R-phycoerythrin (PE). This orange-red dye is efficiently excited at 488 nm and emits at 578 nm.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cathleen Rich et al.
European journal of immunology, 34(5), 1251-1261 (2004-04-29)
The use of HLA class II-transgenic (Tg) mice has facilitated identification of antigenic T cell epitopes that may contribute to inflammation in T cell-mediated diseases such as rheumatoid arthritis and multiple sclerosis (MS). In this study, we compared the encephalitogenic
Chengrui Nan et al.
International journal of molecular medicine, 36(4), 1057-1062 (2015-08-12)
In the present study, human umbilical cord-derived mesenchymal stem cells (hUMSCs) were investigated for their potential to be induced to differentiate in vitro into neuron-like cells by monosialoteterahexosyl ganglioside (GM1). Mononuclear cells obtained from umbilical cords from women with full-term pregnancies whose babies
Joseph J Boyle et al.
The American journal of pathology, 174(3), 1097-1108 (2009-02-24)
Intraplaque hemorrhage accelerates atherosclerosis via oxidant stress and contributes to lesion development and destabilization. Normally, macrophages scavenge hemoglobin-haptoglobin (HbHp) complexes via CD163, and this process provokes the secretion of the anti-inflammatory atheroprotective cytokine interleukin (IL)-10. We therefore tested the hypothesis

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