P8984
Monoclonal Anti-Protein Tyrosine Phosphatase μ antibody produced in mouse
clone SBK10, purified immunoglobulin, buffered aqueous solution
别名:
Anti-PTPμ
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
SBK10, monoclonal
表单
buffered aqueous solution
分子量
antigen 200 kDa
种属反应性
rat, mouse, human, bovine
技术
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1-10 μg/mL
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PTPRM(5797)
mouse ... Ptprm(19274)
rat ... Ptprm(29616)
一般描述
Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. The protein phosphatases can be divided into two main groups: protein tyrosine phosphatases (PTPs) and protein serine/threonine phosphatases (PPs) which remove phosphate from proteins/peptides containing phosphotyrosine (pTyr) or phosphoserine/phosphothreonine (pSer/pThr), respectively. Several of the PTPs are known to control the function of growth factor receptors, many of which are tyrosine kinases encoded by oncogenes. PTPmu participates in homophilic binding of extracellular surface of adjacent cells. PTPmu is reported to be downregulated in glioblastoma in which it regulates cell migration and growth factor-independent survival
Monoclonal Anti-Protein Tyrosine Phosphatase mu recognizes PTPmu isoforms in all mammalian species.
Monoclonal Anti-Protein Tyrosine Phosphatase mu recognizes PTPmu isoforms in all mammalian species.
免疫原
peptide corresponding to amino acid residues 42-60 of PTPμ.
应用
Anti-protein tyrosine phosphatase mu may be used for detection by immunoblotting at a working concentration of 1 to 10 μg/mL. The antibody is suitable for immunoprecipitation.
外形
Solution in phosphate buffered saline with 0.08% sodium azide.
制备说明
Purified from tissue culture supernatant using Protein G.
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储存分类代码
10 - Combustible liquids
法规信息
新产品
此项目有
M F Gebbink et al.
The Journal of biological chemistry, 268(22), 16101-16104 (1993-08-05)
Receptor-like protein tyrosine phosphatases (receptor-PTPs) represent a novel family of transmembrane proteins that are thought to play important roles in cellular regulation. They consist of a cytoplasmic catalytic region, a single transmembrane segment and an extracellular, putative ligand-binding domain, but
Adam M Burgoyne et al.
Neuro-oncology, 11(6), 767-778 (2009-03-24)
The cell-surface receptor protein tyrosine phosphatase mu (PTPmu) is a homophilic cell adhesion molecule expressed in CNS neurons and glia. Glioblastomas (GBMs) are the highest grade of primary brain tumors with astrocytic similarity and are characterized by marked dispersal of
Adam M Burgoyne et al.
Cancer research, 69(17), 6960-6968 (2009-08-20)
Glioblastoma multiforme (GBM), the most common malignant primary brain tumor, represents a significant disease burden. GBM tumor cells disperse extensively throughout the brain parenchyma, and the need for tumor-specific drug targets and pharmacologic agents to inhibit cell migration and dispersal
Ronglin Wang et al.
Cell death & disease, 9(6), 693-693 (2018-06-09)
MiRNAs, a group of powerful modulator of gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step in canonical miRNA biogenesis, is involved in modulating cell survival and
S M Brady-Kalnay et al.
The Journal of biological chemistry, 269(45), 28472-28477 (1994-11-11)
The receptor-type protein tyrosine phosphatase PTP mu comprises an extracellular segment containing a MAM domain, an immunoglobulin domain and four fibronectin type III repeats, a transmembrane segment, and two intracellular PTP domains. We have previously shown that PTP mu binds
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