生物来源
rat
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
5H4, monoclonal
表单
buffered aqueous solution
分子量
antigen 65 kDa
种属反应性
Xenopus, human, mouse
技术
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:5,000-1:10,000 using 293T cells transfected with PP2Aα
同位素/亚型
IgM
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... PPP2CA(5515)
mouse ... Ppp2ca(19052)
一般描述
PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates Ras-1 activation, localization of Sgo1 at centromeres, and chromosome segregation . This enzyme primarily comprises of three components; structural subunit A, regulatory subunit B and catalytic subunit C. The scaffolding subunit A has 2 isoforms (α and β) that have been implicated in tumor suppression
Monoclonal Anti-Protein Phosphatase 2Aα (PP2Aα) antibody is specific for human PP2Aα (approx. 65 kDa) and cross-reacts with Xenopus laevis and mouse PP2Aα. The antibody epitope resides within repeat 1 near the N-terminus of human PP2Aα.
Monoclonal Anti-Protein Phosphatase 2Aα (PP2Aα) antibody is specific for human PP2Aα (approx. 65 kDa) and cross-reacts with Xenopus laevis and mouse PP2Aα. The antibody epitope resides within repeat 1 near the N-terminus of human PP2Aα.
免疫原
Purified human PP2Aα subunit
应用
Monoclonal Anti-Protein Phosphatase 2Aα (PP2Aα) antibody is suitable for use in western blot at a dilution of 1:250 using protein extracts from human mucosal and esophageal tumor tissues . The product may also be used for immunoprecipitation, microarray and indirect ELISA.
外形
Supplied as a culture supernatant containing 15 mM sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
E Kremmer et al.
Molecular and cellular biology, 17(3), 1692-1701 (1997-03-01)
Protein phosphatase 2A (PP2A) holoenzyme is composed of a catalytic subunit, C, and two regulatory subunits, A and B. The A subunit is rod shaped and consists of 15 nonidentical repeats. According to our previous model, the B subunit binds
Anna A Sablina et al.
Cell adhesion & migration, 1(3), 140-141 (2007-07-01)
The protein phosphatase 2A (PP2A) family of heterotrimeric serine-threonine phosphatases participates in human cell transformation. Each functional PP2A complex contains one structural A subunit (A alpha or A beta), and mutations of both are found to occur at low frequency
He-Ge Chen et al.
PloS one, 4(9), e7019-e7019 (2009-09-15)
Protein phosphatases-2A (PP-2A) is a major serine/threonine phosphatase and accounts for more than 50% serine/threonine phosphatase activity in eukaryotes. The holoenzyme of PP-2A consists of the scaffold A subunit, the catalytic C subunit and the regulatory B subunit. The scaffold
Satoshi Ugi et al.
Molecular and cellular biology, 22(7), 2375-2387 (2002-03-09)
Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase that carries out multiple functions. Although numerous observations suggest that PP2A plays a major role in downregulation of the mitogen-activated protein (MAP) kinase pathway, the precise mechanisms are unknown. To clarify
Zhanyun Tang et al.
Developmental cell, 10(5), 575-585 (2006-04-04)
Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, during prophase, and (2) cleavage of centromeric cohesin by
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