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Merck
CN

P9018

佛波醇 12,13-二癸酸佛波醇

solid

别名:

PDD, Phorbol 12,13-dicaprinate

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关于此项目

经验公式(希尔记法):
C40H64O8
化学文摘社编号:
分子量:
672.93
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
6036113
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SMILES string

[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C

form

solid

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

storage temp.

−20°C

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General description

More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent

Biochem/physiol Actions

Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.

Preparation Note

A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Disclaimer

Photosensitive

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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K Hu et al.
The American journal of physiology, 276(2 Pt 2), H488-H495 (1999-02-10)
Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity
I Magiati et al.
Molecular autism, 6, 40-40 (2015-07-01)
There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been
Liliana Garneata et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(1), 67-74 (2014-09-15)
Periodontal disease (PDD) was associated with inflammation, malnutrition, and higher mortality in hemodialysis (HD) patients. Cross-sectional observational study, aiming to assess the prevalence of PDD and the possible relationship among PDD, inflammation, and malnutrition in HD patients. Single HD center
Leandro Francisco S Bastos et al.
European journal of pharmacology, 576(1-3), 171-179 (2007-08-28)
Tetracyclines induce anti-inflammatory effects unrelated to their antimicrobial activities. We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been

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