P9143
佛波醇 12,13-二醋酸盐
powder
别名:
PDA
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H32O8
化学文摘社编号:
分子量:
448.51
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
2317312
MDL number:
SMILES string
C[C@@H]1[C@@H](OC(C)=O)[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
InChI
1S/C24H32O8/c1-11-7-17-22(29,19(11)28)9-15(10-25)8-16-18-21(5,6)24(18,32-14(4)27)20(31-13(3)26)12(2)23(16,17)30/h7-8,12,16-18,20,25,29-30H,9-10H2,1-6H3/t12-,16+,17-,18-,20-,22-,23-,24-/m1/s1
InChI key
OMHXSAMFEJVCPT-XQOWHXTBSA-N
form
powder
color
white
solubility
H2O: soluble
storage temp.
−20°C
General description
Phorbol ester with enhanced hydrophilicity.
Application
Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.
Biochem/physiol Actions
Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK).
Preparation Note
Although having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
Other Notes
Less potent but more water soluble than phorbol 12,13-dibutyrate.
Disclaimer
Photosensitive.
signalword
Danger
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Irene Dini et al.
Antioxidants (Basel, Switzerland), 9(4) (2020-04-02)
Olive trees are grown on five continents. Fertilization of fields, pest control management, olive leaves, olive pomaces, and olive mill wastewaters have a substantial environmental impact. It is possible to reduce this problem by using organic products to cultivate and
Arrestin Translocation in Rod Photoreceptors Is Stimulated by Phorbol 12, 13--diacetate
Orisme W and Smith C
investigate opthalmology and visual science, 46, 1716-1716 (2005)
Josué Delgado et al.
Food microbiology, 84, 103266-103266 (2019-08-20)
Postharvest fungal diseases are among the main causes of fresh fruit losses. Chemical control is against claims for "natural" or "chemical-free" products. Biocontrol agents, such as antifungal proteins or their producing moulds, may serve to combat unwanted pathogens. Since the
Verena Speckbacher et al.
Frontiers in microbiology, 11, 2004-2004 (2020-09-26)
The necrotrophic mycoparasite Trichoderma atroviride is a biological pest control agent frequently applied in agriculture for the protection of plants against fungal phytopathogens. One of the main secondary metabolites produced by this fungus is 6-pentyl-α-pyrone (6-PP). 6-PP is an organic
Mohammadhossein Dabaghi et al.
Micromachines, 12(2) (2021-02-04)
Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and assists the fabrication of complicated geometries at micro- and nano-scales
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持