P9521
21-Deoxycortisol
synthetic (organic), ≥98.00% (TLC), 17-hydroxyprogesterone derivative, powder
别名:
11β,17α-Dihydroxy-4-pregnene-3,20-dione, 11β,17α-Dihydroxyprogesterone, 21-Desoxycortisol, 4-Pregnene-11β,17α-diol-3,20-dione
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关于此项目
经验公式（希尔记法）:
C21H30O4
化学文摘社编号:
分子量:
346.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
211-375-7
MDL number:
产品名称
21-Deoxycortisol,
InChI key
LCZBQMKVFQNSJR-UJPCIWJBSA-N
InChI
1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1
SMILES string
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
biological source
synthetic (organic)
assay
≥98.00% (TLC)
form
powder
solubility
ethanol: 9.80-10.20 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
Quality Level
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Biochem/physiol Actions
21-Deoxycortisol is a 17-hydroxyprogesterone derivative. It serves as a marker for congenital adrenal hyperplasia, an autosomal recessive disorder, indicated by 21-hydroxylase deficiency.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Radha Chaube et al.
Theriogenology, 105, 90-96 (2017-09-25)
In the present study, distribution of steroid hormones (estradiol-17β (E
Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency
Costa BFA, et al.
Clin. Endocrinol., 73(6), 700-706 (2010)
Cristina A Martinez et al.
Genes, 11(8) (2020-08-06)
Anxiety, chronical stress, and depression during pregnancy are considered to affect the offspring, presumably through placental dysregulation. We have studied the term placentae of pregnancies clinically monitored with the Beck's Anxiety Inventory (BAI) and Edinburgh Postnatal Depression Scale (EPDS). A
J Fiet et al.
Annals of clinical biochemistry, 31 ( Pt 1), 56-64 (1994-01-01)
21-deoxycortisol (21-DF) is a steroid of strictly adrenal origin formed by the 11-hydroxylation of 17-hydroxyprogesterone. This metabolic pathway is minor in normal subjects, in whom basal plasma concentrations range from 0.03 to 0.63 nmol/L and from 0.865 to 1.50 nmol/L
M Hill et al.
Steroids, 60(9), 615-620 (1995-09-01)
A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal disorders, is described and evaluated. Antisera against 3-(O-carboxymethyl)oximes conjugated to bovine serum albumin were raised
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