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PLA0038

Goat anti-MCM3 Antibody, Affinity Purified

Name: Goat anti-MCM3 Antibody, Affinity Purified
Brand: SIGMA

Powered by Bethyl Laboratories, Inc.

别名:

DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, HCC5, MCM3 minichromosome maintenance deficient 3, MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), P1-MCM3, P1.h, RLF subunit beta, RLFB, beta subunit, cervical cancer proto-oncogene 5, hRlf beta subunit, minichromosome maintenance deficient (S. cerevisiae) 3, minichromosome maintenance deficient 3, p102, replication licensing factor

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

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biological source

goat

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

immunohistochemistry: 1:200-1:1,000, western blot: 1:2,000- 1:10,000

accession no.

NP_002379.2

UniProt accession no.

P25205

shipped in

wet ice

storage temp.

2-8°C

Gene Information

goat ... MCM3(4172)

Immunogen

The epitope recognized by PLA0038 maps to a region between residues 500 and 550 of human Minichromosome Maintenance 3 using the numbering given in entry NP_002379.2 (GeneID 4172).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM3 has been shown to interact with MCM5, CDC46, and the acetyltransferase MCM3AP.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1.

Kyle P Heim et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(44), 15746-15751 (2014-10-22)

The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. A composite model of P1 based on partial crystal structures revealed an unusual complex architecture in which the protein forms an

PEGylation of microbead surfaces reduces unspecific antibody binding in glycan-based suspension array.

Tatiana Pochechueva et al.

Journal of immunological methods, 412, 42-52 (2014-07-06)

Glycan-based suspension array (SGA) is an "in-house" developed multi-target immunoassay, employing commercially available fluorescent microbeads as a solid support for unique chemically synthesized glycopolymers which capture naturally occurring human anti-glycan antibodies. SGA is a sensitive and reliable tool for the

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