Rabbit anti-Phospho Rad17 (S645) Antibody, Affinity Purified

Immunogen for PLA0052 was a phosphorylated synthetic peptide, which represented a portion of human Rad17 (GeneID 5884) around serine 645 according to the numbering given in entry NP_002864.1.

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Rad17 is a cell cycle checkpoint protein that associates with the RFC complex to recruit the 9-1-1 complex (Rad9, Hus1, Rad1) to sites of DNA damage. At DNA lesions, Rad17 and RFC aid in the activation of Chk2 by ATM and ATRIP to trigger the checkpoint signaling cascade for G2 arrest.

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