Rabbit anti-ATM Antibody, Affinity Purified

The epitope recognized by PLA0086 maps to a region between residues 2550 and 2600 of human ataxia telangiectasia mutated using the numbering given in SwissProt entry Q13315 (GeneID 472).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.

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