Rabbit anti-Chk2 Antibody, Affinity Purified

The epitope recognized by PLA0122 maps to a region between residues 1 and 50 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest.

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