Rabbit anti-Timeless Antibody, Affinity Purified

The epitope recognized by PLA0159 maps to a region between residue 1120 and 1170 of human Timeless using the numbering given in entry NP_003911.1 (GeneID 8914).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Timeless was first identified in Drosophila as a transcriptional regulator involved in the fly circadian rhythm. In mice, humans and yeast, the homologs of drosophila timeless have been observed to play a role in the DNA damage checkpoint response. Human timeless has been shown to interact with the circadian clock protein cryptochrome 2 as well as the DNA checkpoint proteins Chk1 and the ATR-ATRIP complex suggesting a link between circadian rhythm and the cell cycle.

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