Rabbit anti-TLK2 Antibody, Affinity Purified

The epitope recognized by PLA0177 maps to a region between residue 722 and 772 of human tousled-like kinase 2 using the numbering given in entry EAW94344.1 (GeneID 11011).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Tousled-like kinase 2 (TLK2) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The chromatin assembly factor, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2.

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