Rabbit anti-CDC25c Antibody, Affinity Purified

The epitope recognized by PLA0186 maps to a region between residue 150 and 200 of human cell division cycle 25 homolog C using the numbering given in entry NP_001781.2 (GeneID 995).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

CDC25c (cell division cycle 25 homolog c) is a member of the Cdc25 family of phosphatases. CDC25c promotes cell cycle progression and M-phase entry by dephosphorylating CDC2/cyclin B and activating its kinase activity. CDC25c is phosphorylated and activated by multiple kinases including chk1, Cdc2/cyclin B, polo-like kinase 1, and JNK MAP kinases. The inactivation of CDC25c phosphatase activity is achieved through dephosphorylation by PP1 and PP2A phosphatases.

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