Rabbit anti-DBF4 Antibody, Affinity Purified

The epitope recognized by PLA0209 maps to a region between residue 100 and 150 of human DBF4 (activator of S phase kinase) using the numbering given in entry NP_006707.1 (GeneID 10926).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

The DBF4 gene was originally identified in replication mutants of S. cerevisiae that exhibited a “dumbbell former” phenotype characterized by a cell with a single large bud. The human homolog was later isolated in a two-hybrid screen for proteins that interact with the human Cdc7-related kinase (huCdc7), a conserved kinase that phosphorylates MCM2 and MCM3 and is required for the G1/S transition. DBF4 functions as a regulatory subunit for the human Cdc7 kinase and is essential for the initiation of DNA repair.

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