Rabbit anti-NPM1 Antibody, Affinity Purified

The epitope recognized by PLA0254 maps to a region between residue 250 and 294 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. It associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. NPM1 binds ribosomes presumably to drive ribosome nuclear export. Chromosomal aberrations involving NPM1 have been identified in several types of leukemia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P06748].

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