shipped in
wet ice
storage temp.
2-8°C
General description
Proteoprep 20是一种免疫去除试剂盒，可从血浆或血清中去除20种高丰度干扰蛋白，从而分析低丰度蛋白。Proteoprep 20 可去除的蛋白：白蛋白、IgG、转铁蛋白、纤维蛋白原、gA, α2巨球蛋白、IgM, α1抗胰蛋白脢、补体蛋白C3、 触珠蛋白、载脂蛋白A1、载脂蛋白A3和载脂蛋白B；α1酸性糖蛋白、铜蓝蛋白、补体蛋白C4、补体蛋白C1q、IgD、前白蛋白和纤维蛋白溶酶原。
Application
ProteoPrep 20血浆免疫去除试剂盒可从为进一步的蛋白质组分析而制备的人血浆或血清样本中特异性去除20种最高丰度的蛋白质。无论您采用二维还是三维电泳，一维还是多维色谱，亦或是直接进行质谱，这种去除方法均可实现更深的血浆蛋白质组渗透率。这一方法基于小分子量重组免疫亲和配体与可在支撑物上进行高密度偶联的传统抗体的独特偶联过程。可选的配体确保了最佳的特异性。对于人血浆或血清，其典型的总蛋白去除率为97-98%（质量）。
Features and Benefits
• 提高可视化低丰度蛋白和生物标志物的能力 – 可有效去除>99% 的二十种最高丰度蛋白质，可将特定蛋白载量提高50倍，从而增加了低丰度蛋白可视化的几率
• 独特的抗体亲和介质 – 新型高密度抗体亲和介质显示出了更高的特异性，可以减少污染，去除污染物能力相对于所有现有产品大幅提升
• 方便的离心柱形式 – 快速去除污染物和回收，提高了通量和验证能力，成为了所有蛋白质组实验室的首选
• 独特的抗体亲和介质 – 新型高密度抗体亲和介质显示出了更高的特异性，可以减少污染，去除污染物能力相对于所有现有产品大幅提升
• 方便的离心柱形式 – 快速去除污染物和回收，提高了通量和验证能力，成为了所有蛋白质组实验室的首选
Legal Information
ProteoPrep is a registered trademark of Merck KGaA, Darmstadt, Germany
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Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Tara K Sigdel et al.
Pediatric transplantation, 12(7), 737-747 (2008-09-04)
The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. However, the task is daunting
Jon M Jacobs et al.
Journal of proteome research, 4(4), 1073-1085 (2005-08-09)
Candidate proteomic biomarker discovery from human plasma holds both incredible clinical potential as well as significant challenges. The dynamic range of proteins within plasma is known to exceed 10(10), and many potential biomarkers are likely present at lower protein abundances.
Tara K Sigdel et al.
Frontiers in medicine, 4, 80-80 (2017-07-04)
Identification and use of non-invasive biomarkers for kidney transplantation monitoring is an unmet need. A total of 121 biobanked sera collected from 111 unique kidney transplant (KT) patients (children and adolescent) and 10 age-matched healthy normal controls were used to
Removal of albumin from multiple human serum samples.
K Rengarajan et al.
BioTechniques, 20(1), 30-32 (1996-01-01)
N Leigh Anderson et al.
Molecular & cellular proteomics : MCP, 1(11), 845-867 (2002-12-19)
The human plasma proteome holds the promise of a revolution in disease diagnosis and therapeutic monitoring provided that major challenges in proteomics and related disciplines can be addressed. Plasma is not only the primary clinical specimen but also represents the
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Investigation of Non-Specific Protein:Protein Interactions Following Removal of Twenty High Abundance Proteins from Human Plasma
We have developed a novel, high-binding capacity, antibodybased resin for the depletion of twenty high abundance proteins in human plasma. The technology is a significant improvement over existing kits that remove 2, 6, or 12 proteins.
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