PRS2125
Anti-MYD88 (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Myeloid differentiation primary response gene (88)
产品名称
Anti-MYD88 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 35 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYD88(4615)
Biochem/physiol Actions
Myeloid differentiation primary response 88 (MYD88) activates innate immune response to Mycobacterium tuberculosis. It is an activator of nuclear factor κ B (NF-κB).The protein mediates the signaling pathways of toll-like and interleukin-1 receptors. Mutation in the gene encoding MYD88 is associated with diffuse large B-cell lymphoma.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Myeloid differentiation primary response 88 (MYD88) is a cytosolic soluble adaptor protein. It possesses a toll-interleukin 1 receptor domain and a death domain. The gene encoding this protein is localized on human chromosome 3p22.2.
Immunogen
a peptide corresponding to amino acids 233-248 of human MyD88, which differ from mouse by two amino acids.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2125.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
Zhan C
Protein engineering, design & selection : PEDS, 29(9), 347-354 (2016)
Regional copy number?independent deregulation of transcription in cancer
Nicolas Stransky
Nature Genetics, 38(12) (2006)
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