PRS3953
Anti-RIG-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, Anti-Dead box protein 58, Anti-Retinoic acid inducible gene 1 protein, Anti-ddx58
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DDX58(23586)
General description
RIG-1 (retinoic acid-inducible gene I) is a cytoplasmic viral RNA receptor, that is also known as DDX58 (DExD/H-box helicase 58). It belongs to RIG-I-like receptor (RLR) family. It has 2 N-terminal caspase recruitment domains (CARDs), a central RNA helicase domain, and a C-terminal RNA-binding domain. It is located on chromosome 9p21.1.
Immunogen
human GST-tagged RIG-1 protein.
Biochem/physiol Actions
DDX58 (DExD/H-box helicase 58) mutations leads to atypical singleton-merten syndrome. It participates in immune regulation and activation of astrocyte.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
Jang MA, et al.
American Journal of Human Genetics, 96(2), 266-274 (2015)
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis
MacNair L, et al.
Brain, 139(Pt 1), 86-100 (2016)
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate
Lee MK, et al.
Nucleic Acids Research, 44(17), 8407-8416 (2016)
Maurizio Callari et al.
Molecular oncology, 8(7), 1278-1289 (2014-05-24)
The majority of gene expression signatures developed to predict the likelihood to relapse in breast cancer (BC) patients assigns a high risk score to patients with Estrogen Receptor (ER) negative or highly proliferating tumors. We aimed to identify a signature
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