PRS4065
抗PD-1 (ab1) 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗CD279, 抗PDCD1, 抗程序性细胞死亡蛋白1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
indirect ELISA
western blot
immunohistochemistry
indirect ELISA
western blot
Species reactivity:
mouse, human
Citations:
5
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗PD-1 (ab1) 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 32 kDa
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PDCD1(5133)
Biochem/physiol Actions
PD-1（程序性死亡1，programmed death-1）基因对系统性红斑狼疮（SLE）敏感。PD-1的多态性可能参与EOG（上皮性卵巢癌）的生长。它可作为T细胞的负调节剂。它还导致肿瘤细胞介导的免疫逃逸。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
PD-1（程序性死亡受体-1）是一种免疫抑制分子，也称为PDCD1（程序性细胞死亡蛋白1）。它位于染色体2q37.3上。是免疫球蛋白受体超家族的成员之一。
Immunogen
由人PD-1羧基末端附近的16个氨基酸组成的肽。
Other Notes
可以使用阻断肽 SBP4065阻断该抗体的作用。
Physical form
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese
Kong EK, et al.
Arthritis and Rheumatism, 52(4), 1058-1062 (2005)
The effect of polymorphisms in PD-1 gene on the risk of epithelial ovarian cancer and patients' outcomes
Li Y, et al.
Gynecologic Oncology, 144(1), 140-145 (2017)
PD-1 and PD-L1 Expression Levels as a Potential Biomarker of Chronic Rhinosinusitis and Head and Neck Cancers.
Malinowska, et al.
Journal of clinical medicine, 12 (2023)
Julien Rossignol et al.
iScience, 25(6), 104353-104353 (2022-07-26)
Targeting immune checkpoints, such as Programmed cell Death 1 (PD1), has improved survival in cancer patients by restoring antitumor immune responses. Most patients, however, relapse or are refractory to immune checkpoint blocking therapies. Neuropilin-1 (NRP1) is a transmembrane glycoprotein required
Gang Chen et al.
Nature neuroscience, 20(7), 917-926 (2017-05-23)
Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and suppresses immunity through the receptor PD-1 expressed on T cells. However, the role of PD-L1 and PD-1 in regulating pain and neuronal function is unclear. Here we report
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