PZ0018
醋酸巴多昔芬
≥98% (HPLC), Selective estrogen receptor modulator (SERM), powder
别名:
1-[4-(2-氮杂-1-基-乙氧基)苄基] -2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇乙酸酯, TSE-424, WAY-140424, WAY-TSE-424
产品名称
醋酸巴多昔芬, ≥98% (HPLC)
SMILES string
[N+H]5(CCCCCC5)CCOc1ccc(cc1)C[n]2c3c(c(c2c4ccc(cc4)O)C)cc(cc3)O.[O-]C(=O)C
InChI
1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)
InChI key
OMZAMQFQZMUNTP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
醋酸巴泽多昔芬已被用于研究其在抑制白介素6（IL-6）/IL-6R/糖蛋白130途径中的功效，及其对髓母细胞瘤细胞的作用。
Biochem/physiol Actions
苯卓昔芬属于第三代非甾体选择性雌激素受体调节剂（SERM）。
苯卓昔芬属于第三代非甾体选择性雌激素受体调节剂（SERM），在临床上用于治疗绝经后骨质疏松。苯卓昔芬可以IC50 = 26 nM与雌激素受体-α结合，这与雷洛昔芬相似，但低于17-β雌二醇的亲和力。 苯卓昔芬并不能刺激MCF-7细胞的增殖，反而会以IC50 = 0.19 nM抑制17β -雌二醇诱导的增殖，表现出了理想的激动剂/拮抗剂活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Blanca D López-Ayllón et al.
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Yanan Chen et al.
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Adam T Szafran et al.
iScience, 25(10), 105200-105200 (2022-10-15)
The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-HeLa cell models expressing either inducible C-terminal (iGFP-ER) or
Jing Li et al.
Clinical and translational medicine, 11(12), e627-e627 (2021-12-20)
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