PZ0115
CP-31398 二盐酸盐 水合物
≥98% (HPLC)
别名:
N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C22H26N4O·2HCl · xH2O
分子量:
435.39 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
storage condition
desiccated
color
yellow
solubility
H2O: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
InChI
1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
InChI key
JXIVIAMOMIONKY-UWCBQFGESA-N
Gene Information
human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)
Application
CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:
- to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
- to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
- to study its effects on regulation of miR-34 in PC12 cells
Biochem/physiol Actions
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.
CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
hcodes
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable