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About This Item
经验公式（希尔记法）:
C22H26N4O·2HCl · xH2O
分子量:
435.39 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
储存条件
desiccated
颜色
yellow
溶解性
H2O: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
InChI
1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
InChI key
JXIVIAMOMIONKY-UWCBQFGESA-N
基因信息
human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)
应用
CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:
- to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
- to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
- to study its effects on regulation of miR-34 in PC12 cells
生化/生理作用
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.
CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
特点和优势
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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