PZ0297
PF-06305591 二水合物
≥98% (HPLC)
别名:
(αR,βS)-β-Amino-6-(1,1-dimethylethyl)-α-methyl-1H-benzimidazole-2-propanamide dihydrate
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H22N4O · 2H2O
化学文摘社编号:
分子量:
310.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
C[C@@H](C(N)=O)[C@H](N)C1=NC2=CC(C(C)(C)C)=CC=C2N1
InChI
1S/C15H22N4O/c1-8(13(17)20)12(16)14-18-10-6-5-9(15(2,3)4)7-11(10)19-14/h5-8,12H,16H2,1-4H3,(H2,17,20)(H,18,19)/t8-,12+/m1/s1
InChI key
APWZIFIAVVFPNT-PELKAZGASA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
PF-06305591 is safe and has acceptable absorption, distribution, metabolism, and elimination (ADME) properties.
PF-06305591 is a potent and highly selective sodium channel Nav1.8 inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alan D Brown et al.
Bioorganic & medicinal chemistry, 27(1), 230-239 (2018-12-13)
The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持