产品名称
帕博昔利, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
0.1 M HCl: 2 mg/mL, clear
storage temp.
room temp
SMILES string
CC(C1=C(N2C3CCCC3)N=C(NC4=CC=C(N5CCNCC5)C=N4)N=C1)=C(C(C)=O)C2=O
InChI
1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChI key
AHJRHEGDXFFMBM-UHFFFAOYSA-N
Biochem/physiol Actions
PF-00080665(Palbociclib;PD 0332991)是一种靶向周期蛋白依赖性激酶4&6(使用CDK4/cycD3、CDK4/cycD1、CDK6/cycD2的IC50分别为9、11、15 nM;靶向其他36种激酶的IC50为>10 μM)的口服活性且高度特异性的抑制剂,其可有效抑制Cdk4/6依赖性细胞Rb磷酸化过程(IC50 = 66 nM/pSer780 & 63 nM/pSer795; MDA-MB-435)。PF-00080665对Rb阳性的人乳腺癌/结肠癌/肺癌/白血病细胞具有选择性的抗增殖活性(IC50 = 40-400 nM;IC50 >3 μM/Rb阴性MDA-MB-468 & H2009),并且在体内显示出对小鼠多种晚期人类肿瘤异种移植物的有效(12.5-150 mg/kg/day p.o.)。
Preparation Note
该化学品可以溶液形式在-80°C保存6个月,-20°C下1个月(避光)。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Muta. 2 - Repr. 2 - STOT RE 2 Oral
target_organs
Bone marrow,male reproductive organs
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fiona J Ruiz et al.
Cancers, 13(18) (2021-09-29)
Cervical cancer tumors with undetectable HPV (HPVU) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPVU tumors to date (HPVU = 35, HPV+ = 430). Genomic
Xiaoyang Li et al.
Cell death & disease, 9(5), 446-446 (2018-04-20)
Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma
ER
Angel L Guerrero-Zotano et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(11), 2517-2529 (2018-03-28)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PZ0383-25MG | 04061838691163 |
| PZ0383-5MG | 04061838691170 |

