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PZ0393

Oxamniquine

≥98% (HPLC)

别名:

(2-((isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl)methanol, 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol

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关于此项目

经验公式（希尔记法）:
C14H21N3O3
化学文摘社编号:
21738-42-1
分子量:
279.33
UNSPSC Code:
41121800
NACRES:
NA.77
MDL number:
MFCD00866725
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

faint yellow to dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

[N+](=O)([O-])c1cc2c(cc1CO)CCC(N2)CNC(C)C

InChI

1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3

InChI key

XCGYUJZMCCFSRP-UHFFFAOYSA-N

Biochem/physiol Actions

Oxamniquine is an anthelmintic agent with schistosomicidal activity against Schistosoma mansoni.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000086450
0000086451
0000075940

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Anastasia Rugel et al.
ACS medicinal chemistry letters, 9(10), 967-973 (2018-10-23)
Schistosomiasis is a major human parasitic disease afflicting more than 250 million people, historically treated with chemotherapies praziquantel or oxamniquine. Since oxamniquine is species-specific, killing Schistosoma mansoni but not other schistosome species (S. haematobium or S. japonicum) and evidence for
Gordana Panic et al.
Antimicrobial agents and chemotherapy, 61(12) (2017-10-04)
To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to
Lidiany da Paixão Siqueira et al.
Acta tropica, 176, 179-187 (2017-08-15)
Neglected tropical diseases (NTDs) affect millions of people in different geographic regions, especially the poorest and most vulnerable. Currently NTDs are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. One of the most