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Merck
CN

Q0125

Sigma-Aldrich

槲皮素 二水合物

≥98% (HPLC), powder

别名:

2-（3,4-二羟基苯基）-3,5,7-三羟基-4 H -1-苯并吡喃-4-酮 二水合物, 3,3′,4′,5,7-五羟基黄酮 二水合物

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关于此项目

经验公式（希尔记法）:
C15H10O7 · 2H2O
化学文摘社编号:
6151-25-3
分子量:
338.27
颜色索引号:
75670
Beilstein:
317313
EC 号:
204-187-1
UNSPSC代码:
12352207
PubChem化学物质编号:
24278668

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方案

≥98% (HPLC)

表单

powder

颜色

yellow

mp

>300 °C (lit.)

溶解性

1 M NaOH: 50 mg/mL

SMILES字符串

OC(C(O)=C1)=CC=C1C2=C(O)C(C3=C(O)C=C(O)C=C3O2)=O

InChI

1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2

InChI key

GMGIWEZSKCNYSW-UHFFFAOYSA-N

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生化/生理作用

槲皮素二水合物是具有抗癌活性的黄酮类化合物。
槲皮素二水合物是具有抗癌活性的黄酮类化合物。槲皮素为线粒体 ATP 酶和磷酸二酯酶抑制剂。它可抑制 PI3 激酶活性并且轻微抑制 PIP 激酶活性。槲皮素对癌细胞系具有抗增殖作用，通过 II 型雌激素受体降低癌细胞的生长，并且阻滞细胞周期晚期 G1 相中人类白血病 T 细胞。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
068K0676
038F0542
087K0744
116K1836
117H0860

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Product Q0125, Quercetin dihydrate, soluble in?

    This product is soluble in DMSO (24 mg/mL). Per chemicals encyclopedia published by the Royal Society of Chemistry 12th ed., entry #8216, 1 g of quercetin dissolves in 290 mL absolute ethanol or 23 ml hot ethanol. It is soluble in glacial acetic acid and alkaline aqueous solutions but it is practically insoluble in water.

  4. What is the solution stability of Product Q0125, Quercetin dihydrate?

    We have no data on solution stability. It is best to store solutions protected from air, the colder the better to minimize oxidation.

  5. What is the shelf life of Product Q0125, Quercetin dihydrate?

    This product does not have an assigned shelf life or expiration date.  So the standard Sigma-Aldrich guarantee of one year from date of receipt applies.

  6. Is Product Q0125, Quercetin dihydrate,synthetic?

    An initial amino acid used in the product is from plant source (Rutin); the final product is chemically synthesized.

  7. Where would you recommend that we store Product Q0125, Quercetin dihydrate?

    Powdered quercetin dihydrate should be stored at ambient temperature, in a cool dry place. Refrigeration is not necessary.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

M Yoshida et al.
Cancer research, 52(23), 6676-6681 (1992-12-01)
The effect of quercetin, a flavonoid found in many plants, on the proliferation of human leukemic T-cells was analyzed. Quercetin reversibly blocked the cell cycle at a point 3-6 h before the start of DNA synthesis. Expression of the growth-related
R L Singhal et al.
Biochemical and biophysical research communications, 208(1), 425-431 (1995-03-08)
Signal transduction activity was markedly elevated in cancer cells as shown by the increased activity of enzymes utilizing 1-phosphatidylinositol, PI (PI 4-kinase and PI-4-phosphate 5-kinase) for the production of the second messenger inositol 1,4,5-trisphosphate, IP3, in rat hepatomas (Cancer Res.
Sze-Wing Mok et al.
Cartilage, 11(4), 490-499 (2018-08-31)
Quercetin (Que), a bioflavonoid, is both anti-inflammatory and antioxidative. Que has been used as an oral supplement for osteoarthritis (OA) with inconsistent findings because of its low bioavailability. We encapsulated Que in a mPEG-polypeptide thermogel to prolong its bioactivity. The
Soheil Fereidouni et al.
Journal of biochemical and molecular toxicology, 33(8), e22341-e22341 (2019-04-17)
Chlorpyrifos (CPF), an organophosphate insecticide has a wider application throughout the world to protect agricultural crops and vegetables from insects. Polyphenolic compounds are considered as beneficial against toxicities induced by organophosphates. The present study was conducted to understand the neuroprotective
A Beretz et al.
Experientia, 34(8), 1054-1055 (1978-08-15)
The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of which have a potency equivalent to that of papaverine. Some
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