主要文件

查看所有文档

Q1250

奎宁半硫酸盐一水合物

Name: 奎宁 半硫酸盐 一水合物
Brand: SIGMA

synthetic, ≥90% (HPLC), Potassium channel blocker

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O

化学文摘社编号:

207671-44-1

分子量:

391.47

NACRES:

NA.77

PubChem Substance ID:

57654578

UNSPSC Code:

12352210

MDL number:

MFCD00150790

Beilstein/REAXYS Number:

6113937

Assay:

≥90% (HPLC)

Quality level:

200

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

奎宁半硫酸盐一水合物, synthetic, ≥90% (HPLC)

biological source

synthetic

Quality Level

200

assay

≥90% (HPLC)

mp

~225 °C (dec.) (lit.)

solubility

H₂O: slightly soluble 1.2 mg/mL, ethanol: 8 mg/mL

antibiotic activity spectrum

parasites

mode of action

enzyme | inhibits

originator

Bayer

SMILES string

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

InChI key

ZHNFLHYOFXQIOW-LPYZJUEESA-N

正在寻找类似产品? 访问产品对比指南

Application

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Biochem/physiol Actions

Quinine has analgesic property.

钾通道阻滞剂。抗疟疾

钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂；最初从南美树木的金鸡纳科中分离出来的生物碱。

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Investigation of the presynaptic effects of quinine and quinidine on the release and uptake of monoamines in rat brain tissue.

E M Clement et al.

Neuropharmacology, 37(7), 945-951 (1998-10-17)

Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine

Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.

A Hedman et al.

Journal of pharmaceutical sciences, 87(4), 457-461 (1998-04-21)

The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. In

Sex Differences in Binge-Like and Aversion-Resistant Alcohol Drinking in C57BL/6J Mice.

Elizabeth A Sneddon et al.

Alcoholism, clinical and experimental research, 43(2), 243-249 (2018-11-16)

Alcohol use disorder is characterized by compulsive alcohol intake, or drinking despite negative consequences. Previous studies have shown that female rodents have a heightened vulnerability to drug use across different stages of the addictive cycle, but no previous studies have

Both perceptual and conceptual factors influence taste-odor and taste-taste interactions

Frank RA, et al.

Perception & Psychophysics, 54(3), 343-354 (1993)

Quinine-induced inhibition of gastrointestinal transit in mice: possible involvement of endogenous opioids.

F A Santos et al.

European journal of pharmacology, 364(2-3), 193-197 (1999-02-05)

The effect of quinine, a cinchona alkaloid, was studied on gastrointestinal transit in mice. Intraperitoneal (i.p.) administration of quinine inhibited the intestinal propulsion of a charcoal suspension at a dose of 100 mg/kg, comparing favorably with 5 mg/kg morphine. In

查看所有相关文献

商品

Discover Bioactive Small Molecules for ADME/Tox

全球贸易项目编号

货号	GTIN
Q1250-50G	04061836687786
Q1250-10G	04061836687779
Q1250-5G	04061836687793

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持