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Merck
CN

Q1250

奎宁 半硫酸盐 一水合物

synthetic, ≥90% (HPLC), Potassium channel blocker

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关于此项目

经验公式（希尔记法）:
C20H24N2O2 · 0.5H2O4S · H2O
化学文摘社编号:
207671-44-1
分子量:
391.47
NACRES:
NA.77
PubChem Substance ID:
57654578
UNSPSC Code:
12352210
MDL number:
MFCD00150790
Beilstein/REAXYS Number:
6113937

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产品名称

奎宁 半硫酸盐 一水合物, synthetic, ≥90% (HPLC)

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

SMILES string

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI key

ZHNFLHYOFXQIOW-LPYZJUEESA-N

biological source

synthetic

assay

≥90% (HPLC)

mp

~225 °C (dec.) (lit.)

solubility

H2O: slightly soluble 1.2 mg/mL
ethanol: 8 mg/mL

antibiotic activity spectrum

parasites

mode of action

enzyme | inhibits

originator

Bayer

Quality Level

200

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相关类别

Biochem/physiol Actions

钾通道阻滞剂。抗疟疾
钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂；最初从南美树木的金鸡纳科中分离出来的生物碱。
Quinine has analgesic property.

Application

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
MKCW6194
MKCR0808
MKCQ1053
MKCM9633
MKCG3675

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F A Santos et al.
European journal of pharmacology, 364(2-3), 193-197 (1999-02-05)
The effect of quinine, a cinchona alkaloid, was studied on gastrointestinal transit in mice. Intraperitoneal (i.p.) administration of quinine inhibited the intestinal propulsion of a charcoal suspension at a dose of 100 mg/kg, comparing favorably with 5 mg/kg morphine. In
Elizabeth A Sneddon et al.
Alcoholism, clinical and experimental research, 43(2), 243-249 (2018-11-16)
Alcohol use disorder is characterized by compulsive alcohol intake, or drinking despite negative consequences. Previous studies have shown that female rodents have a heightened vulnerability to drug use across different stages of the addictive cycle, but no previous studies have
Both perceptual and conceptual factors influence taste-odor and taste-taste interactions
Frank RA, et al.
Perception & Psychophysics, 54(3), 343-354 (1993)
A Hedman et al.
Journal of pharmaceutical sciences, 87(4), 457-461 (1998-04-21)
The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. In
E M Clement et al.
Neuropharmacology, 37(7), 945-951 (1998-10-17)
Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine
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