R0529
Ro 90-7501
≥98% (HPLC)
别名:
2′-(4-Aminophenyl)-[2,5′-bi-1H-benzimidazol]-5-amine
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关于此项目
经验公式（希尔记法）:
C20H16N6
化学文摘社编号:
分子量:
340.38
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C20H16N6/c21-13-4-1-11(2-5-13)19-23-15-7-3-12(9-17(15)25-19)20-24-16-8-6-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)
SMILES string
Nc1ccc(cc1)-c2nc3ccc(cc3[nH]2)-c4nc5ccc(N)cc5[nH]4
InChI key
PAGZCEHLFCJSPV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
brown
solubility
DMSO: ~20 mg/mL, H2O: insoluble
originator
Roche
Biochem/physiol Actions
Inhibitor of Aß42 fibril formation
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
B Bohrmann et al.
Journal of structural biology, 130(2-3), 232-246 (2000-08-15)
Assemblyof the amyloid-beta peptide (Abeta) into fibrils and its deposition in distinct brain areas is considered responsible for the pathogenesis of Alzheimer's disease (AD). Thus, inhibition of fibril assembly is a potential strategy for therapeutic intervention. Electron cryomicroscopy was used
Christopher A Ross et al.
Nature medicine, 10 Suppl, S10-S17 (2004-07-24)
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates
Zhihao Li et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 148, 21-29 (2020-04-21)
Radiotherapy plays a crucial role in the treatment of cervical cancer, but existing radiosensitizers have limited efficacy in clinical applications. The aims of this study were to establish and verify an efficient method for identifying new radiosensitizers, to use this
Sally Park et al.
Small GTPases, 12(2), 147-160 (2019-10-12)
Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation of downstream processes. Fgd5 is a Rho GEF involved in
Katelyn E Zulauf et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(47), 29839-29850 (2020-11-11)
Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant pathogens for which new treatments are desperately needed. Carbapenemases and other types of antibiotic resistance genes are carried almost exclusively on large, low-copy-number plasmids (pCRE). Accordingly, small molecules that efficiently evict pCRE plasmids should restore
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