R106
Ro 16-6491 hydrochloride
solid
别名:
N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C9H11ClN2O · HCl
化学文摘社编号:
分子量:
235.11
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
表单
solid
颜色
white
mp
216-217 °C
溶解性
H2O: soluble
SMILES字符串
Cl.NCCNC(=O)c1ccc(Cl)cc1
InChI
1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H
InChI key
ARUMZUNJBHSOQQ-UHFFFAOYSA-N
基因信息
human ... MAOB(4129)
生化/生理作用
Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
G P Bondiolotti et al.
Biochemical pharmacology, 50(1), 97-102 (1995-06-29)
To investigate whether the reversible monoamine oxidase-B (MAO-B) inhibitors lazabemide and Ro 16-6491 have any additional effect on monoamine uptake and release, in vitro experiments were performed on rat forebrain synaptosomes and blood platelets. The effects of the two drugs
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
A M Cesura et al.
Pharmacological research communications, 20 Suppl 4, 51-61 (1988-12-01)
B Vallès et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(10), 1101-1111 (1993-10-01)
1. Moclobemide, an inhibitor of monoamine oxidase, shows mixed MAO A/B inhibition in rat, but pure MAO A inhibition in man. This is attributed to a primary amine metabolite which inhibits MAO B in vitro, but which is not detected
E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
M Da Prada et al.
Advances in neurology, 45, 175-178 (1987-01-01)
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