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Merck
CN

R109

Sigma-Aldrich

Ro 15-4513

solid

别名:

Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, Ro15-4513

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About This Item

经验公式(希尔记法):
C15H14N6O3
CAS Number:
分子量:
326.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

表单

solid

质量水平

颜色

tan

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
H2O: insoluble
methanol: soluble

创始人

Roche

SMILES字符串

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-]

InChI

1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

CFSOJZTUTOQNIA-UHFFFAOYSA-N

应用

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats[1] and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.[2]

生化/生理作用

Ro 15-4513 is benzodiazepine receptor partial inverse agonist.[3] It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region.[3] Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.[4]

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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