R130
RJR-2403 hemigalactarate
≥98% (HPLC), powder
别名:
N-Methyl-4-(3-pyridinyl]-3-buten-1-amine hemigalactarate
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: 1 mg/mL
H2O: 20 mg/mL
储存温度
2-8°C
SMILES字符串
CNCC\C=C\c1cccnc1
生化/生理作用
Neuronal nicotinic acetylcholine receptor agonist that displays CNS activity.
免责声明
Photosensitive
法规信息
新产品
此项目有
Pharmacological characterization of RJR-2403: A nicotinic agonist with potential therapeutic benefit in the treatment of Alzheimer's disease.
Bencherif, M.
Cns Drug Reviews, 3, 325-325 (1997)
P M Lippiello et al.
The Journal of pharmacology and experimental therapeutics, 279(3), 1422-1429 (1996-12-01)
We have evaluated the physiological and behavioral effects of the CNS-selective nicotinic agonist (E)-N-methyl-4-(3-pyridinyl) -3-butene-1-amine (RJR-2403) using a number of different methods, including 1) reversal of pharmacologically induced amnesia in a step-through passive avoidance paradigm, 2) radial arm maze performance
M Bencherif et al.
The Journal of pharmacology and experimental therapeutics, 279(3), 1413-1421 (1996-12-01)
Increasing evidence for an involvement of nicotinic cholinergic systems in neurodegenerative disorders has stimulated the search for compounds with selectivity for CNS nicotinic ACh receptors (nAChRs). To this end, we have evaluated a number of nicotinic agonists for their ability
K L Summers et al.
Neurochemical research, 21(10), 1181-1186 (1996-10-01)
Transcortical dialysis was employed to investigate the effects of subcutaneous (s.c.) injections of RJR-2403 (1.2-7.2 mumol/kg) on extracellular levels of acetylcholine (ACh), norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in rat. Systemic administration of RJR-2403 produced a 90% increase of
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