R136
Ro 31-8220 甲磺酸盐
solid
别名:
2-{1-[3-（脒基）丙基]-1H-吲哚-3-基}-3-（1-甲基吲哚-3-基）马来酰亚胺 甲磺酸盐, 双吲哚基马来酰亚胺IX
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关于此项目
线性分子式:
C25H23N5O2S · CH3SO3H
化学文摘社编号:
分子量:
553.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
SMILES string
CS(O)(=O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(N)=N)c4ccccc34)c5ccccc15
InChI key
SAWVGDJBSPLRRB-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
color
orange to red
solubility
H2O: 7.3 mg/mL
storage temp.
2-8°C
General description
Ro 31-8220是星形孢菌素的一种双吲哚基马来酰亚胺衍生物。Ro 31-8220可阻断MAP激酶磷酸酶-1（MKP-1）的表达、诱导c-Jun表达并刺激Jun N末端激酶（JNK1）。它具有免疫抑制特性。
Biochem/physiol Actions
抑制GRK-5（G蛋白偶联受体激酶）；PKC（蛋白激酶C）；MAPKAP激酶1β及p70 S6激酶。
Features and Benefits
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ro 31-8220, A Novel Protein Kinase C Inhibitor, Inhibits Early And Late T Cell Activation Events1
Geiselhart L, et al.
Transplantation, 61(11), 1637-1642 (1996)
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase
Beltman J, et al.
The Journal of Biological Chemistry, 271(43), 27018-27024 (1996)
J Beltman et al.
The Journal of biological chemistry, 271(43), 27018-27024 (1996-10-25)
The role of protein kinase C (PKC) in inflammation, mitogenesis, and differentiation has been deduced in part through the use of a variety of PKC inhibitors. Two widely used inhibitors are the structurally related compounds GF109203X and Ro-31-8220, both of
D R Alessi
FEBS letters, 402(2-3), 121-123 (1997-02-03)
The protein kinase C (PKC) inhibitors Ro 318220 and GF 109203X have been used in over 350 published studies to investigate the physiological roles of PKC. Here we demonstrate that these inhibitors are not selective for PKC isoforms as was
Diana Rey et al.
Cell calcium, 80, 56-62 (2019-04-10)
Astragalin is a flavonol glycoside with several biological activities, including antidiabetic properties. The objective of this study was to investigate the effects of astragalin on glycaemia and insulin secretion, in vivo, and on calcium influx and insulin secretion in isolated
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