R2778
RU 28362
≥98% (HPLC), solid
别名:
(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one
方案
≥98% (HPLC)
表单
solid
杂质
1.25 mol/mol Ethanol
溶解性
DMSO: soluble 33 mg/mL
储存温度
2-8°C
SMILES字符串
CC#C[C@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
基因信息
rat ... Nr3c1(24413)
生化/生理作用
Glucocorticoid receptor agonist.
法规信息
新产品
此项目有
U S Sandau et al.
Neuroscience, 144(2), 482-494 (2006-11-18)
Neonatal administration of the synthetic glucocorticoid, dexamethasone (DEX) retards brain growth, alters adult behaviors and induces cell death in the rat brain, thereby implicating glucocorticoids as developmentally neuroendangering compounds. Glucocorticoids also increase expression of pro-apoptotic Bcl-2 family members and exacerbate
Taiki Takahashi et al.
Journal of neurochemistry, 83(6), 1441-1451 (2002-12-11)
This work reports the first demonstration that corticosterone (CORT) has a rapid and transient effect on NMDA receptor-mediated Ca2+ signaling in cultured rat hippocampal neurons. Using single cell Ca2+ imaging, CORT and agonists of glucocorticoid receptors were observed to modulate
Areg Barsegyan et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(38), 16655-16660 (2010-09-03)
It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated
Benno Roozendaal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(45), 14299-14308 (2009-11-13)
Considerable evidence indicates that the basolateral complex of the amygdala (BLA) interacts with efferent brain regions in mediating glucocorticoid effects on memory consolidation. Here, we investigated whether glucocorticoid influences on the consolidation of memory for emotionally arousing training depend on
Abigail B Ginsberg et al.
Stress (Amsterdam, Netherlands), 13(3), 248-257 (2010-04-16)
The hypothalamic-pituitary-adrenal (HPA) axis self-regulates through a glucocorticoid negative feedback mechanism that is stereotypically slow and long lasting. Rapid (seconds to minutes) glucocorticoid feedback, however, inhibits stress-induced adrenocorticotropic hormone (ACTH) secretion too quickly to result from classic transcriptional effects of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持