R2778
RU 28362
≥98% (HPLC), solid
别名:
(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one
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关于此项目
经验公式（希尔记法）:
C23H28O3
化学文摘社编号:
分子量:
352.47
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
SMILES string
CC#C[C@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
assay
≥98% (HPLC)
form
solid
impurities
1.25 mol/mol Ethanol
solubility
DMSO: soluble 33 mg/mL
storage temp.
2-8°C
Gene Information
rat ... Nr3c1(24413)
Biochem/physiol Actions
Glucocorticoid receptor agonist.
法规信息
新产品
此项目有
Igor Allaman et al.
Journal of neurochemistry, 88(4), 900-908 (2004-02-06)
Glucocorticoids (GC) are considered as key modulators of glycogen homeostasis in peripheral tissues, but their role in the central nervous system has only partially been characterized. Exposure of primary cultures of cortical astrocytes to dexamethasone (DEX), a synthetic glucocorticoid, results
Benno Roozendaal et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(3), 1328-1333 (2003-01-23)
Previous studies have indicated that stress-activated glucocorticoid hormones induce temporary memory retrieval impairment. The present study examined whether adrenal steroid receptors in the hippocampus mediate such glucocorticoid effects on spatial memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta, 17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one
Benno Roozendaal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(6), 1385-1392 (2004-02-13)
Previous findings indicate that the basolateral complex of the amygdala (BLA) interacts with other brain regions in regulating stress hormone effects on memory functions. Lesions of the BLA or infusions of a beta-adrenoceptor antagonist into the BLA block glucocorticoid effects
Benno Roozendaal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(37), 8161-8169 (2004-09-17)
Previous findings indicate that administration of abeta-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that beta-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids
A B Ginsberg et al.
Journal of neuroendocrinology, 15(11), 1075-1083 (2003-11-19)
Corticosterone regulates both basal and stress-induced hypothalamic-pituitary-adrenal (HPA) axis activity in a negative-feedback fashion. However, the cellular and molecular mechanisms of this negative feedback have yet to be explicitly characterized. By comparing stress-induced c-fos and corticotropin-releasing hormone (CRH) expression in
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