R3277
吴茱萸次碱
>98% (HPLC)
别名:
8,13-二氢吲哚[2′,3′3,4]吡啶并[2,1-b] 喹唑啉-5 (7H)-酮, 吴茱萸次碱, 松树树脂
质量水平
方案
>98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble 18 mg/mL (clear yellow solution)
H2O: insoluble
储存温度
2-8°C
SMILES字符串
O=C1N2CCc3c([nH]c4ccccc34)C2=Nc5ccccc15
InChI
1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
InChI key
ACVGWSKVRYFWRP-UHFFFAOYSA-N
基因信息
human ... CYP1A1(1543), CYP1A2(1544), CYP1B1(1545)
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生化/生理作用
延迟整流 K + 通道阻滞剂。抑制血小板聚集;输精管扩张器。
警示用语:
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Min Tong et al.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 42(2), 234-236 (2011-04-20)
To study the effect of Rutaecarpine on the treatment of atopic dermatitis in mice. DNCB was repeatedly applied on the back of NC/Nga mice to establish the animal model of atopic dermatitis. The mice without and with treatments with various
Tiandong Bao et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(24), 3519-3522 (2012-03-01)
Develop an LC-MS method to determine evodiamine and rutaecarpine in rats plasma simultaneously. The method was employed to investigate pharmacokinetics of evodiamine and rutaecarpine. Blood samples were collected in different time after oral administrated with the extracts of Euodiae Fructus
Chongliang Lin et al.
Die Pharmazie, 66(12), 920-923 (2012-02-09)
A sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method for the determination of evodiamine and rutecarpine in rabbit plasma was developed and validated. The analytes and internal standard (IS) are extracted from plasma by one-step protein precipitation with acetonitrile, and
Ben Liu et al.
Journal of chromatography. A, 1217(50), 7833-7839 (2010-11-12)
Evodiamine and rutaecarpine have been intensively studied due to their pharmacological actions and clinical applications. In this report, supercritical fluid was used to extract evodiamine and rutaecarpine from the unripe fruit of Evodia rutaecarpa. Response surface methodology using Box-Behnken experimental
Chuan-Qin Hu et al.
Journal of Asian natural products research, 14(4), 370-381 (2012-03-02)
A simple and sensitive high-performance liquid chromatographic method was developed for the simultaneous determination and pharmacokinetic analysis of seven alkaloids dehydroevodiamine (DHED), 10-hydroxyrutaecarpine (HDR), evodiamine (EDM), rutaecarpine (RCP), 1-methyl-2-n-nonyl-4(1H)quinolone (MNQ), evocarpine (ECP), and dihydroevocarpine (DHE), and two flavonoids isorhamnetin-7-O-rutinoside (RIM)
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