R4282
RF9 trifluoroacetate salt
≥97% (HPLC)
别名:
1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C26H38N6O3 · xC2HF3O2
化学文摘社编号:
分子量:
482.62 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
InChI
1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1
InChI key
GPVFYPYIOXHDCU-CFIUKZCSSA-N
assay
≥97% (HPLC)
solubility
H2O: 20 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
RF9 is a neuropeptide FF receptor antagonist.
RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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