R6275
Anti-phospho-Retinoblastoma (pSer780) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
mouse, human, rat
技术
western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer780)
基因信息
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
一般描述
RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.
免疫原
synthetic peptide corresponding to residues around pSer780 of the human retinoblastoma tumor suppressor protein (Rb).
生化/生理作用
RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.
Recognizes Rb phosphorylated at Ser780 and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.
外形
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.
制备说明
Purified using protein A and affinity chromatography.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
法规信息
新产品
此项目有
A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Alessandro Poli et al.
Journal of cellular physiology, 232(9), 2550-2557 (2016-10-13)
Phosphatidylinositol (PI) signaling is an essential regulator of cell motility and proliferation. A portion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持