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R8279

RG108

Name: RG108
Brand: SIGMA

≥98% (HPLC), DNA methyltransferase (DMNT) inhibitor, powder

别名:

N-酞酰-L-色氨酸

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₄N₂O₄

化学文摘社编号:

48208-26-0

分子量:

334.33

UNSPSC Code:

12352200

PubChem Substance ID:

24724594

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

RG108, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -250 to -310°, c = 0.5 in methanol

color

yellow

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O

InChI

1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

InChI key

LMAZUAXDZRILNJ-INIZCTEOSA-N

说明

General description

RG108是一种非核苷类似物，也称为[2-(1,3-二氧异吲哚啉-2-基)-3-(1H-吲哚-3-基)丙酸。

Application

RG108可用于：

重编程和提高原代多能间充质干细胞 (MMSC) 的可塑性。
作为人视网膜色素上皮细胞ARPE-19中的DNA甲基转移酶抑制剂 (DNMTi)。
作为C33A2细胞的DNA甲基转移酶抑制剂，检测其对乳头瘤病毒晚期基因表达 (HPV16) 的影响。

Biochem/physiol Actions

RG108是一种DNA甲基转移酶（DMNT）抑制剂。

RG108是一种DNA甲基转移酶（DMNT）抑制剂。它通过DNA去甲基化重新激活肿瘤细胞中的肿瘤抑制基因表达（p16，SFRP1，分泌性卷曲相关蛋白-1和TIMP-3）。RG108还能抑制人肿瘤细胞系（HCT116，NALM-6）增殖并增加培养的倍增时间。

Rg108的细胞毒性低于氮杂胞苷 (5-Aza-dCR)。它介导食道癌细胞 (EC) 的辐射敏感性。RG108是有效的表观遗传调控剂和去甲基化剂。它不会引起细胞毒性，可用于基于人骨髓间充质干细胞 (hBMSC) 的干细胞治疗。它作用于DNA甲基转移酶1的催化结构域。

Features and Benefits

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

5-Azacytidine specifically inhibits the NIH-3T3 PCD process induced by TNF-alpha and cycloheximide via affecting BCL-XL.

Qing Wang et al.

Journal of cellular biochemistry, 119(2), 1501-1510 (2017-08-05)

DNA methylation plays a crucial role in lots of biological processes and cancer. 5-azacytidine (5-AC), a DNA methylation inhibitor, has been used as a potential chemotherapeutic agent for cancer. In this study, we used 5-AC treatment to investigate whether DNA

DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer.

Yao Ou et al.

Oncology reports, 39(3), 993-1002 (2018-01-13)

Esophageal cancer (EC) is the eighth most common highly aggressive cancer worldwide. The purpose of this study was to investigate the effect of the DNA methyltransferase inhibitor RG108 on the radiosensitivity of EC cells. MTT and clonogenic assays were performed

Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes.

Paulina Tokarz et al.

European journal of pharmacology, 776, 167-175 (2016-02-24)

Epigenetic modifications influence DNA damage response (DDR). In this study we explored the role of DNA methylation and histone acetylation in DDR in cells challenged with acute or chronic oxidative stress. We used retinal pigment epithelial cells (ARPE-19), which natively

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全球贸易项目编号

货号	GTIN
R8279-10MG	04061836823764