R9157
Ro 4-1284
≥98% (HPLC)
别名:
2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine
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关于此项目
经验公式（希尔记法）:
C21H33NO3
化学文摘社编号:
分子量:
347.49
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98% (HPLC)
form
solid
solubility
DMSO: 16 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C
InChI
1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
InChI key
TUNMGCULOKMBNJ-UHFFFAOYSA-N
Biochem/physiol Actions
Ro 4-1284 is a reversible VMAT2 inhibitor.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
M E Maragoudakis et al.
Kidney international, 43(1), 147-150 (1993-01-01)
Basement membrane (BM) exerts profound influence on endothelial cell (EC) behavior. In addition BM is a structural element of blood vessels; in fact at some point of their formation blood vessels are bare EC tubes lined with the BM produced
M E Maragoudakis et al.
Microvascular research, 50(2), 215-222 (1995-09-01)
A method providing a biochemical index for the evaluation of promoters or inhibitors of angiogenesis in the chick chorioallantoic membrane (CAM) is here described and validated. This method is based on the determination of collagenous protein synthesis which takes place
S Yehuda et al.
European journal of pharmacology, 365(1), 27-34 (1999-02-13)
Ro4-1284 (2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a] quinolizin-2-ol hydrochloride), a benzoquinolizine, is a potent dopamine depletion agent whose acute and chronic administration results in a (1) deterioration of learning in the Morris Water Maze and passive avoidance tasks, (2) decrease in locomotion and rearing, (3)