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Merck
CN

S002

Sigma-Aldrich

(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐

solid

别名:

(±)-2-二丙基氨基-8-羟基-1,2,3,4-四氢萘, (±)-8-Hydroxy-2-(dipropylamino)tetralin, (±)-8-OH-DPAT

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关于此项目

经验公式（希尔记法）:
C16H25NO · HBr
化学文摘社编号:
87394-87-4
分子量:
328.29
MDL编号:
MFCD00055158
UNSPSC代码:
12352100

主要文件

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表单

solid

颜色

white to tan

溶解性

ethanol: 10 mg/mL
H2O: 5 mg/mL
0.1 M HCl: 7 mg/mL

SMILES字符串

Br[H].CCCN(CCC)C1CCc2cccc(O)c2C1

InChI

1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H

InChI key

BATPBOZTBNNDLN-UHFFFAOYSA-N

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生化/生理作用

Selective 5-HT1A serotonin receptor agonist.

免责声明

Light sensitive

法规信息

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分析证书(COA)

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H Gozlan et al.
Nature, 305(5930), 140-142 (1983-09-08)
Binding studies with appropriate labelled ligands have revealed the existence of two types of serotonin (5-HT) receptor, 5-HT1 and 5-HT2, in the central nervous system of mammals. The 5-HT1 type is characterized by a higher affinity for agonists than for
E Mizuta et al.
European journal of pharmacology, 178(1), 125-127 (1990-03-13)
Subcutaneous injections of a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in monkeys induced distinct behavioural changes characterized by head weaving, hindlimb extension and upper limb fluttering. The effects were dose-dependent and were similar to the 5-HT syndrome induced in rats by
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
D N Middlemiss et al.
European journal of pharmacology, 90(1), 151-153 (1983-05-20)

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