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Merck
CN

S0137

Secretin porcine

≥97% (HPLC), synthetic

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关于此项目

经验公式（希尔记法）:
C130H220N44O41
化学文摘社编号:
17034-35-4
分子量:
3055.41
EC Number:
241-105-3
UNSPSC Code:
51111800
PubChem Substance ID:
24899429
Beilstein/REAXYS Number:
741850
MDL number:
MFCD00133810

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InChI key

KYSAMAXXLYMNME-INRVZKLKSA-N

InChI

1S/C130H220N44O41.6C4H7NO4/c1-59(2)41-79(119(208)173-99(65(13)14)102(134)191)152-94(183)52-148-105(194)76(31-34-92(132)181)157-114(203)82(44-62(7)8)164-116(205)83(45-63(9)10)162-108(197)73(28-22-38-145-128(137)138)154-111(200)77(32-35-93(133)182)158-115(204)81(43-61(5)6)160-107(196)72(27-21-37-144-127(135)136)153-103(192)66(15)151-121(210)88(54-175)169-118(207)87(50-98(189)190)166-110(199)74(29-23-39-146-129(139)140)155-113(202)80(42-60(3)4)161-109(198)75(30-24-40-147-130(141)142)156-122(211)90(56-177)170-117(206)84(46-64(11)12)163-112(201)78(33-36-96(185)186)159-123(212)91(57-178)171-126(215)101(68(17)180)174-120(209)85(47-69-25-19-18-20-26-69)167-125(214)100(67(16)179)172-95(184)53-149-106(195)86(49-97(187)188)165-124(213)89(55-176)168-104(193)71(131)48-70-51-143-58-150-70;6*5-2(4(8)9)1-3(6)7/h18-20,25-26,51,58-68,71-91,99-101,175-180H,21-24,27-50,52-57,131H2,1-17H3,(H2,132,181)(H2,133,182)(H2,134,191)(H,143,150)(H,148,194)(H,149,195)(H,151,210)(H,152,183)(H,153,192)(H,154,200)(H,155,202)(H,156,211)(H,157,203)(H,158,204)(H,159,212)(H,160,196)(H,161,198)(H,162,197)(H,163,201)(H,164,205)(H,165,213)(H,166,199)(H,167,214)(H,168,193)(H,169,207)(H,170,206)(H,171,215)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147);6*2H,1,5H2,(H,6,7)(H,8,9)/t66-,67+,68+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,99-,100-,101-;6*2-/m0000000/s1

SMILES string

[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O

biological source

synthetic

assay

≥97% (HPLC)

UniProt accession no.

P63298

storage temp.

−20°C

Gene Information

pig ... SCT(397464)

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Biochem/physiol Actions

Stimulates secretion of carbonate-rich pancreatic fluid; relaxes smooth muscle

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
025K4818
118F48384
058H4952
058H49521
040K49511

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Xin-Yi Chen et al.
Neuroscience letters, 532, 29-32 (2012-11-15)
The paraventricular nucleus (PVN) of hypothalamus is a major integrative center in homeostatic control. Morphological studies have revealed a high level of secretin and secretin receptor expression in the PVN. To investigate the direct electrophysiological effects of secretin in the
Yasuhisa Mori et al.
Pancreas, 42(2), 187-192 (2013-02-15)
The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease
Revathi Sekar et al.
General and comparative endocrinology, 181, 18-24 (2012-12-19)
Secretin (Sct), traditionally a gastrointestinal hormone backed by a century long research, is now beginning to be recognized also as a neuroactive peptide. Substantiation by recent evidence on the functional role of Sct in various regions of the brain, especially
Maoqing Dong et al.
Regulatory peptides, 180, 5-11 (2012-11-13)
Understanding of the structural importance of each position along a peptide ligand can provide important insights into the molecular basis for its receptor binding and biological activity. This has typically been evaluated using serial replacement of each natural residue with
Yuji Nishikawa et al.
Journal of cellular biochemistry, 114(4), 831-843 (2012-10-26)
We previously showed that mature hepatocytes could transdifferentiate into bile ductular cells when placed in a collagen-rich microenvironment. To explore the mechanism of transdifferentiation, we examined whether inflammatory cytokines affected the phenotype of hepatocytes in a three-dimensional culture system. Spheroidal
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